Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. Stage I Melanoma. Melanoma Clinical Trials. 70208. Part 2 will further evaluate the safety and efficacy at the pediatric RP2D. Location: 13 locations, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial), A Study to Compare the Administration of Pembrolizumab after Surgery Versus Administration both before and after Surgery for High-Risk Melanoma, Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients with Stage III-IV BRAFV600 Melanoma, A Phase II / III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients with Advanced Melanoma, Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients with Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial, Pembrolizumab in Treating Patients with Desmoplastic Melanoma That Can or Cannot Be Removed by Surgery, A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma with Brain Metastases, Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders with HRAS Gene Alterations, a Pediatric MATCH Treatment Trial, Dabrafenib, Trametinib, and Navitoclax in Treating Patients with BRAF Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery, Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1 / 2 / 3 (Trk A / B / C), ROS1, or ALK Gene Rearrangements (Fusions), A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051 / KEYNOTE-051), An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis, A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors. IMPORTANT: Listing a study does not mean it has been evaluated by the U.S. Federal Government.Read our disclaimer for details.. Before participating in a study, talk to your health care provider and learn about the risks and potential benefits. During the Phase 1 dose escalation portion of the trial, NKTR-262 will be combined with systemic administration of bempegaldesleukin. A phase 2 trial of dasatinib in melanoma was conducted to assess response rate (RR), progression-free survival (PFS), and toxicity. 6654, (Canada) Dr. Xinni Song, Ottawa Hospital Research Institute, (613) 737-7700 Ext. The Phase 2 dose expansion is designed to provide a preliminary estimate of efficacy in patients that have progressed on an anti-PD-(L)1 CPI. Location: 15 locations, This study will evaluate the efficacy, safety, pharmacokinetics, and patient-reported outcomes (PROs) of RO7198457 plus pembrolizumab compared with pembrolizumab alone in patients with previously untreated advanced melanoma. The study will concurrently enroll patients with four distinct advanced malignancies in 5 separate tumor cohorts. You may want to think about taking part in a clinical trial. A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma, Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Advanced Solid Tumors, Study of NGM120 in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy, Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors, A Study of NKTR-262 in Combination With Bempegaldesleukin (NKTR-214) and With Bempegaldesleukin Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies, A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER), A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3), QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors, A Study of XmAb®22841 Monotherapy & in Combination w / Pembrolizumab in Subjects w / Selected Advanced Solid Tumors, Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients, Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer, U.S. Department of Health and Human Services. Call 1-888-624-1937 or submit an inquiry. Dabrafenib and trametinib may block tumor growth by targeting the BRAFV600 gene. Location: 36 locations, This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1 / 2 / 3, ROS1, or ALK gene fusion. Clinical Trials; Cutaneous Melanoma. Seit 2003 nutzt NCI Informationen aus Studien zu Hundekrebs, um Studien zu Krebs beim Menschen und umgekehrt zu leiten – ein Bereich, der als vergleichende Onkologie bezeichnet wird. Treatment will continue for up to 2 years, or until the patient experiences confirmed progressive disease or unacceptable toxicity, withdraws consent, or if the Investigator feels it is no longer in the patient's best interest to continue treatment. Deputy Director for Clinical& Translational Research National Cancer Institutes of Health. You may want to think about taking part in a clinical trial. All trials on the list are supported by NCI. Enrollment of participants with MSI-H and TMB-H solid tumors also continues. Patients in the MCC cohort will receive IT cavrotolimod combined with a fixed, standard dose of pembrolizumab while the CSCC cohort will receive IT cavrotolimod combined with a fixed, standard dose of cemiplimab. Diagnosis (Mucosal) Treatment (Mucosal) Resources (Mucosal) Pediatric & AYA Melanoma. This trial is being done to determine if doctors can safely shorten the use of standard of care anti-PD1 therapy for melanoma by using biomarkers seen on PET / CT imaging and tumor biopsy. Giving pembrolizumab before and after surgery may work better compared to after surgery alone in treating melanoma. NCI-MATCH is the first trial to establish the likelihood of identifying targeted treatments for patients with relapsed, refractory cancers–both common and rare. 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