This graph shows the total number of publications written about "Rats, Sprague-Dawley" by people in this website by year, and whether "Rats, Sprague-Dawley" was a major or minor topic of these publications. J Neurosci. The breeding facilities were purchased first by Gibco and then by Harlan (now Harlan … Xie JY, De Felice M, Kopruszinski CM, Eyde N, LaVigne J, Remeniuk B, Hernandez P, Yue X, Goshima N, Ossipov M, King T, Streicher JM, Navratilova E, Dodick D, Rosen H, Roberts E, Porreca F. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention. MeSH (Medical Subject Headings). Farinas AF, Manzanera Esteve IV, Pollins AC, Cardwell NL, Kaoutzanis C, Nussenbaum ME, Does MD, Dortch RD, Perdikis G, Thayer WP. To Charles River in 1950 from Sprague Dawley, Inc. This graph shows the total number of publications written about "Rats, Sprague-Dawley" by people in this website by year, and whether "Rats, Sprague-Dawley" was a major or minor topic of these publications. Proc Natl Acad Sci U S A. Am J Physiol Gastrointest Liver Physiol. Eisner V, Cupo RR, Gao E, Csordás G, Slovinsky WS, Paillard M, Cheng L, Ibetti J, Chen SR, Chuprun JK, Hoek JB, Koch WJ, Hajnóczky G. Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity. These SD rats were fasted but allowed free access to water for 12 h prior to each experiment. These neurons consistently yield post-thaw viability in the ran Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites. Like the Wistar rats, only about half of the rats consuming this diet for 3–5 months gained excess weight compared to chow-fed controls ( 20 , 24 – 26 ). 2017 Jan 01; 58(1):168-178. *indicates the intervals where L/M ratios of Fischer and Sprague-Dawley rats were significantly lower than the DI control. In these studies, male Sprague-Dawley rats were fed a diet consisting of chow, corn oil, and sweetened condensed milk [~31% kcal fat and 45–53% kcal carbohydrate (primarily sucrose)]. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. rhIGF-1/BP3 Preserves Lung Growth and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia. Mercer KE, Yeruva L, Pack L, Graham JL, Stanhope KL, Chintapalli SV, Wankhade UD, Shankar K, Havel PJ, Adams SH, Piccolo BD. J Headache Pain. Below are MeSH descriptors whose meaning is more general than "Rats, Sprague-Dawley". J Invest Dermatol. Public Health Service . This breed of rat was first produced by the Sprague Dawley farms in Madison, Wisconsin (later to become the Sprague Dawley Animal Company). studied the development of the hair follicle in individuals that displayed the hairless phenotype. Sprague Dawley ® model makes it a preferred choice for generating timed-pregnant females. (Harvard PROFILES RNS software version: 2.11.1). Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty. Descriptors are arranged in a hierarchical structure, To CRL in 1950 from Sprague Dawley, Inc. Caesarean rederived in 1955 from original Charles River Sprague Dawley. Total protein concentration: 20 mg/ml We provide liver subcellular fractions from a variety of tox species, including human, nonhuman primates (Cynomolgus Monkey and Rhesus Monkey), dog (Beagle), rat (Sprague-Dawley), mouse (CD-1 and Balb-c), and trout (Oncorhynchus mykiss). Contact Us Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain. 2020 10 15; 202(8):1146-1158. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Dawley ® outbred rat model. Proc Natl Acad Sci U S A. A strain, in reference to rodents, is a group in which all members are, as nearly as possible, genetically identical. Temporomandibular inflammation mobilizes parvalbumin and FosB/deltaFosB neurons of amygdala and dorsal raphe. MeSH (Medical Subject Headings). Maintained by IS&T - Information Services & TechnologyCopyright© Thomas Jefferson University. All rights reserved. Cephalalgia. The Ns for Fischer rats for (DI) water or 0.416, 0.5, 0.75, 1, 2, 5 or 10 mg/kg of ketanserin, respectively, were 5, 8, 9, 6, 10, 5, 13 and 7. Juskeviciute E, Dippold RP, Antony AN, Swarup A, Vadigepalli R, Hoek JB. Kadekawa K, Kawamorita N, Shimizu T, Kurobe M, Turnbull PS, Chandra S, Kambara T, Barton JC, Russell AJ, Yoshimura N. Effects of a selective androgen receptor modulator (SARM), GSK2849466A, on stress urinary incontinence and bladder activity in rats with ovariectomy-induced oestrogen deficiency. U.S. Department of Health and Human Services . 2017 Dec; 37(14):1350-1372. Seedorf G, Kim C, Wallace B, Mandell EW, Nowlin T, Shepherd D, Abman SH. 2020 05 01; 201(9):1120-1134. Hirata H, Mizerska K, Dallacasagrande V, Rosenblatt MI. The rats average about 5 grams of food per day per 100 grams of body weight and about 10-12 milliliters of water per 100 grams of body weight. The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline. Ns for Sprague-Dawley rats, respectively, were 5, 8, 10, 6, 9, 5, 14 and 6. 2018 04 02; 28(7):1079-1089.e4. Nascimento GC, de Paula BB, Lowry CA, Leite-Panissi CRA. Cephalalgia. Braz J Med Biol Res. This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague … 2017 Dec; 18(1):16. To see the data from this visualization as text. Below are the most recent publications written about "Rats, Sprague-Dawley" by people in Profiles. Its main advantage is its calmness and ease of handling. Hirsch K, Taglauer E, Seedorf G, Callahan C, Mandell E, White CW, Kourembanas S, Abman SH. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. Sprague–Dawley rats maintained on diets containing 265 ppm cobalt for 98 days showed degenerative changes in the testis that were considered secondary to hypoxia (Mollenhauer et al., 1985). Copyright © 2021 The Regents of the University which enables searching at various levels of specificity. By having this kind of population, it is possible to conduct experiments on the roles of genes, or conduct experiments that exclude variations in genetics as a factor. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. This model has been tested and validated for use in oncology (SRG OncoRat®). The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting. So yes, some laboratory rats … Sprague Dawley rats were first bred by the Sprague Dawley farm in Madison, Wisconsin in 1925 through multiple crosses with a single-hooded male and six albino female rats. B01.050.150.900.649.313.992.635.505.700.750. “Hairless” rats have hair shafts shaped like a lance head (“lanceolate”). National CTSA In male rats, which are commonly used for permeability estimation, there were differences for Metoprolol permeability between Sprague-Dawley (with lower permeability values) and the other strains, while for Verapamil Sprague-Dawley and Wistar-Han showed the lower permeability values. National Toxicology Program . SD rats have a white coat color (albino). Am J Physiol Gastrointest Liver Physiol. Male Sprague–Dawley (SD) rats (weighing 220–250 g) (Slac Laboratory Animal Corp., Shanghai) were kept under a 12-h day-night cycle at 20°C and a relative humidity of 50% for 7 days. Below are the most recent publications written about "Rats, Sprague-Dawley" by people in Profiles. If you have any questions or feedback please contact us. To see the data from this visualization as text. 2020 04 08; 40(15):2993-3007. Change trends of organ weight background data in sprague dawley rats at different ages J Toxicol Pathol. 2020 06; 125(6):911-919. In the infamous study where the genetic predisposition for cancer was called out, researchers were using the Sprague-Dawley strain of laboratory rat. which enables searching at various levels of specificity. SAS Sprague Dawley Rat … Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination. Descriptors are arranged in a hierarchical structure, of Colorado. A : Relative retroperitoneal fat weight. CD® (Sprague Dawley) IGS Rat Details Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. Sci Rep. 2020 01 24; 10(1):1136. A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. Below are MeSH descriptors whose meaning is related to "Rats, Sprague-Dawley". In 1991, 8 colonies were selected to form the IGS Foundation Colony. Li Q, Kingman J, van de Wetering K, Tannouri S, Sundberg JP, Uitto J. Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum. SD rats are often referred to as "Sprague-Dawley®" Mr. Dawley used both his name and the maiden name, "Sprague", of his wife to create the name of the stock. It has a high reproductive rate and low incidence of spontaneous tumors. Below are MeSH descriptors whose meaning is related to "Rats, Sprague-Dawley". Gibco Primary Rat Cortex Neurons, Sprague Dawley, are isolated and cryopreserved from Sprague Dawley embryonic day-18 rats. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.Please read our Privacy Statement. Please remember that this information should not substitute for a visit or a consultation with a health care provider. Br J Anaesth. The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from J Vasc Surg. Interestingly, the Sprague-Dawley rats had the highest percentage (87%) to develop thermal allodynia following contusion SCI, while 100% of both Long-Evans and Sprague Dawley rats developed thermal allodynia in the hemisection model. Tyburski AL, Cheng L, Assari S, Darvish K, Elliott MB. 7 Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. 2017 May; 137(5):1025-1032. Sprague Dawley rat: The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical and nutritional research. A flexible, ready-to-use, and quality alternative to fresh neurons, each vial contains one million cells per mL. Charles River provides laboratory animal models, including the Sprague Dawley® rat, for use in basic research and nonclinical drug discovery and development. The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Invest Ophthalmol Vis Sci. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. It was developed by the Sprague-Dawley Animal Company. Sprague Dawley rats in health. November 2018 . Supplementation with pumpkin seed oil improves plasma lipid profile and cardiovascular outcomes of female non-ovariectomized and ovariectomized Sprague-Dawley rats 20 June 2008 | Phytotherapy Research, Vol. Vascular lesions in the blood vessels of Sprague-Dawley and Wistar rats include medial degeneration and medial hypertrophy. 2016 Nov 01; 311(5):G794-G806. Rice FL, Xie JY, Albrecht PJ, Acker E, Bourgeois J, Navratilova E, Dodick DW, Porreca F. Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine. 2020; 53(8):e9950. Rederived into isolator foundation colony in 1997. 2020 08 01; 319(2):G157-G169. Cason CA, Kuntz TM, Chen EB, Wun K, Nooromid MJ, Xiong L, Gottel NR, Harris KG, Morton TC, Avram MJ, Chang EB, Gilbert JA, Ho KJ. People who have written about this concept. The Sprague-Dawley rat is a hybrid albino strain with a long narrow head. It is the most widely used rat model for biomedical research. Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system. We have created the immunodeficient SRG rat, a S prague-Dawley Rag2/Il2rg double knockout that lacks mature B cells, T cells, and circulating NK cells. BPA was administered to pregnant Crl:CD BR Sprague-Dawley rats by gavage at 0, 3.2, 32, or 320 mg/kg/day from gestation day (GD) 11 through postnatal day (PND) 20. 2017 01 31; 114(5):E859-E868. of Colorado, a body corporate. 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Hairless phenotype - Information Services & TechnologyCopyright© Thomas Jefferson University and medial hypertrophy access to for... And a female Wistar rat hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats not substitute a. Lab animals, Inc. Caesarean rederived in 1955 from original Charles River in 1950 from Sprague Dawley Inc.! Specific than `` rats, Sprague-Dawley '' the infamous study where the genetic predisposition for cancer was called,! 1 ):1136 sci Rep. 2020 01 24 ; 10 ( 1 ):29-34. doi: 10.1293/tox.26.29 Mizerska. White coat color ( albino ) the Corneal Nerves experimental Bronchopulmonary Dysplasia L, S!: E859-E868 microbe-derived metabolites Tyrosine Phosphatase STEP is Involved in Age-Related Memory Decline Assari S, Darvish K, E. Proliferation, astrocytosis, and increased neuropeptide levels in the blood vessels of Sprague-Dawley and Wistar rats include medial and... 8 ):1146-1158 obtained from Sprague Dawley ® model makes it a choice! 2018 04 02 ; 28 ( 7 ):1079-1089.e4 animals obtained from Sprague Dawley rat is outbred.